What is the role of ferumoxytol in endovascular aortic repair surveillance for patients with renal impairment?

Label:chem

Topic
Ferumoxytol is an ultrasmall superparamagnetic iron oxide particle that has minimal nephrotoxicity and is not associated with nephrogenic systemic fibrosis (NSF). It is FDA-approved for iron deficiency anemia and has been used off-label as a contrast agent for magnetic resonance imaging (MRI)/magnetic resonance angiography (MRA). This study explores its use in endovascular aortic repair (EVAR) surveillance for patients with renal impairment, particularly those with end-stage renal disease (ESRD).

From: "Ferumoxytol-enhanced magnetic resonance angiography for endovascular aortic repair surveillance in a patient after renal transplant", Journal of Vascular Surgery Cases, Innovations and Techniques, Volume 11, Issue 5, October 2025, 101898
Answer
Ferumoxytol serves as a safe and effective alternative contrast agent for MRI/MRA in patients with renal impairment undergoing EVAR surveillance. It enables high-quality imaging for detecting endoleaks without compromising renal function. In the case presented, ferumoxytol-enhanced MRA (Fe-MRA) successfully identified a type II endoleak that was not previously detected by computed tomography angiography (CTA). This highlights ferumoxytol's potential for improving diagnostic accuracy in EVAR surveillance for patients with compromised renal function.
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