What role does Artesunate (ART) play in the treatment of hepatic fibrosis?

Label:chem

Topic
Hepatic fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) components, leading to liver scarring. ART has been explored for its potential anti-fibrotic effects.
Answer
ART exerts anti-fibrotic effects by inhibiting the activation and proliferation of hepatic stellate cells (HSCs), which are key players in ECM production. It induces ferroptosis in activated HSCs, leading to their death and reducing collagen production. Additionally, ART suppresses the TGF-β1/Smad2/3 signaling pathway, which is central to fibrogenesis.
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