What is the role of Artesunate (ART) in modulating inflammation and oxidative stress in digestive diseases?

Label:chem

Topic
Inflammation and oxidative stress are key contributors to the pathogenesis of various digestive diseases, including gastric ulcers and ulcerative colitis. ART has been shown to exhibit anti-inflammatory and antioxidant properties.
Answer
ART reduces the expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, and inhibits the NF-κB signaling pathway, thereby mitigating inflammation. Additionally, ART increases antioxidant enzyme levels (e.g., SOD, GSH) and reduces oxidative stress markers (e.g., MDA), thus protecting against oxidative damage in digestive tissues.
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