How does Artesunate (ART) impact the adhesion and motility of bladder cancer cells?

Label:chem

Topic
Tumor cell adhesion and motility are critical steps in the metastatic process. Inhibiting these processes can prevent tumor cell dissemination and metastasis.
Answer
Artesunate (ART) significantly inhibits the adhesion of bladder cancer cells to collagen and vascular endothelium. It also impairs cell motility by reducing chemotaxis, migration, and invasion in a cell type-dependent manner. ART achieves these effects by down-regulating the expression of key integrins (α2, α3, α6, β1) and integrin-related signaling proteins (FAK, pFAK, ILK). These findings suggest that ART can effectively reduce the metastatic potential of bladder cancer cells by targeting their adhesion and motility mechanisms.
Return to Home Chemical List
Knowledge you may be interested in
What is the effect of Artesunate (ART) on the metastatic behavior of cisplatin-resistant bladder cancer cells? How does Artesunate (ART) affect integrin expression in bladder cancer cells? What role does Artesunate (ART) play in inhibiting metastatic potential in bladder cancer cells? How does almorexant affect spermatogenesis in healthy male subjects? What is the effect of almorexant on tear film break-up time (TFBUT) in healthy male subjects? How does almorexant affect hormone levels in healthy male subjects? What is the mechanism of action of almorexant, the dual orexin receptor antagonist (DORA)? What is the role of orexin-A and orexin-B in the regulation of arousal and sleep-wake balance? What are the implications of TAK-285's activity in a brain metastasis model? How does TAK-285 perform in in vivo xenograft tumor models? What is the role of integrins in the metastatic potential of bladder cancer cells, and how does Artesunate (ART) modulate their expression? What is the role of Artesunate (ART) in modulating inflammation and oxidative stress in digestive diseases? How does Artesunate (ART) affect Helicobacter pylori (H. pylori) in the context of gastric ulcers? What is the mechanism by which Artesunate (ART) induces apoptosis in cancer cells? How does Artesunate (ART) inhibit the proliferation of cancer cells in digestive system cancers? What role does Artesunate (ART) play in the treatment of hepatic fibrosis? What is the role of cisplatin in the aMVAC regimen? What is the role of methotrexate in the aMVAC regimen? What is the role of vinblastine in the aMVAC regimen? What is the role of doxorubicin in the aMVAC regimen?