How is carboplatin dosing calculated in the DD-MVACarbo regimen?

Label:chem

Topic
Carboplatin dosing in chemotherapy regimens often requires careful calculation based on renal function.
Answer
Carboplatin doses are calculated using the Calvert formula, with a target AUC of 4–5. The formula is:
Carboplatin dose (mg)=target AUC×[GFR (mL/min)+25]
where GFR (glomerular filtration rate) is estimated using the Cockcroft-Gault equation.
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