What role does Artesunate (ART) play in inhibiting metastatic potential in bladder cancer cells?

Label:chem

Topic
Artesunate (ART) is a semi-synthetic derivative of artemisinin, a natural compound extracted from the wormwood plant. It is known for its anti-tumor properties and has been shown to inhibit growth in various cancer cell lines, including cisplatin-resistant bladder cancer (BCa) cells.
Answer
Artesunate (ART) significantly reduces tumor cell adhesion to vascular endothelium and immobilized collagen in both parental and cisplatin-resistant bladder cancer cells. It also suppresses tumor cell motility, including chemotaxis, migration, and invasion. ART achieves this by down-regulating the expression of integrins (both surface and total) and integrin-related signaling proteins such as focal adhesion kinase (FAK) and integrin-linked kinase (ILK). These effects collectively inhibit the metastatic potential of bladder cancer cells, making ART a promising treatment option for advanced or therapy-resistant bladder cancer.
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