How does Artesunate (ART) affect Helicobacter pylori (H. pylori) in the context of gastric ulcers?

Label:chem

Topic
H. pylori infection is a major cause of gastric ulcers and can lead to chronic gastritis and even gastric cancer. ART has been explored for its antimicrobial properties against H. pylori.
Answer
ART effectively inhibits the growth of H. pylori and reduces its adhesion to gastric epithelial cells. It also diminishes reactive oxygen species (ROS) production induced by H. pylori and suppresses the activation of NF-κB, thereby reducing inflammation and promoting healing of gastric ulcers.
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