What is the effect of Artesunate (ART) on the metastatic behavior of cisplatin-resistant bladder cancer cells?

Label:chem

Topic
Cisplatin resistance is a significant challenge in the treatment of bladder cancer, leading to poor prognosis and increased metastatic potential. New therapeutic strategies are needed to overcome this resistance and improve patient outcomes.
Answer
Artesunate (ART) significantly inhibits the metastatic behavior of cisplatin-resistant bladder cancer cells by reducing their adhesion to collagen and vascular endothelium. ART also suppresses chemotaxis, migration, and invasion in these cells. This effect is achieved through the down-regulation of integrin expression and integrin-related signaling pathways. Specifically, ART reduces the expression of integrins α2, α3, α6, and β1, as well as signaling proteins FAK, pFAK, and ILK. These alterations collectively diminish the metastatic potential of cisplatin-resistant bladder cancer cells, making ART a potential therapeutic option for overcoming treatment resistance.
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