What is the role of methotrexate in the aMVAC regimen?

Label:chem

Topic
Methotrexate is part of the aMVAC regimen used for neoadjuvant chemotherapy in muscle-invasive urothelial cancer.
Answer
Methotrexate is one of the key components of the aMVAC regimen. It is administered at a dose of 30 mg/m² on day one of the biweekly cycles. It helps in achieving tumor regression and is part of the combination therapy that enhances the overall efficacy of the regimen.
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