What is the role of ciliobrevin A (CilioA) in modulating cancer cell resistance to VBL?

Label:chem

Topic
Ciliobrevin A is a known inhibitor of ciliogenesis, the process of primary cilium formation.
Answer
Ciliobrevin A treatment reduces primary cilium frequency and enhances cancer cell sensitivity to VBL, indicating that inhibiting ciliogenesis can reverse VBL resistance. This suggests that ciliogenesis inhibitors like CilioA could be potential therapeutic agents to overcome drug resistance in cancer cells.
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