How does Artesunate (ART) affect integrin expression in bladder cancer cells?

Label:chem

Topic
Integrins are adhesion receptors that play a crucial role in cell adhesion, migration, and invasion during tumor metastasis. The expression and function of integrins are often altered in cancer cells, contributing to their metastatic potential.
Answer
Artesunate (ART) significantly down-regulates the expression of several integrins, including α2, α3, α6, and β1, in both parental and cisplatin-resistant bladder cancer cells. This down-regulation occurs at both the cell surface and total protein levels. Additionally, ART reduces the expression of integrin-related signaling proteins such as FAK, pFAK, and ILK. These changes in integrin expression and signaling contribute to the reduced adhesion, migration, and invasion capabilities of bladder cancer cells treated with ART.
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