What role does vinblastine (VBL) play in cancer cell resistance?

Label:chem

Topic
Vinblastine (VBL) is a microtubule destabilizer used in cancer treatment. However, cancer cells can develop resistance to VBL, which is a major challenge in cancer therapy.
Answer
Vinblastine induces anticancer drug resistance in HeLa human cervical cancer cells by promoting primary cilium (PC) formation through NPHP3-mediated pathways. This resistance is associated with increased expression of NPHP3 and IFT88, as well as the apoptosis-antagonizing transcription factor (AATF).
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