What is the effect of almorexant on tear film break-up time (TFBUT) in healthy male subjects?

Label:chem

Topic
A study evaluated the effect of almorexant on ophthalmological variables, including tear film break-up time (TFBUT), which assesses the stability of the tear film.
Answer
The administration of almorexant 200 mg once daily for 4 weeks did not increase the incidence of TFBUT ≤10 seconds compared to placebo. In fact, almorexant was not inferior to placebo in maintaining tear film stability, as evidenced by the lower incidence of TFBUT ≤10 seconds in the almorexant group (18.5%) compared to the placebo group (29.6%).
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