What is the effect of the crude extract from Bacillus nakamurai Tie-10 on the biofilm formation of Klebsiella pneumoniae?

Label:chem

Topic
Biofilms are protective structures formed by bacteria that enhance their resistance to antibiotics and host immune defenses. The study investigates whether the crude extract from Bacillus nakamurai Tie-10 can inhibit biofilm formation by Klebsiella pneumoniae.

From: "Optimization of Fermentation Conditions for Antarctic Bacteria and Investigation of Its Antimicrobial Mechanism Against Klebsiella pneumoniae", Microorganisms 2025, 13(9), 2027;
Answer
The crude extract from Bacillus nakamurai Tie-10 significantly inhibits biofilm formation in Klebsiella pneumoniae in a concentration-dependent manner. At a concentration of 2 MIC, the extract achieves a maximum biofilm suppression rate of 51.63%, nearly completely inhibiting biofilm development.
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