What challenges are associated with the industrial-scale production of nicotinamide mononucleotide (NMN)?

Label:chem

Topic
Early industrial-scale production of NMN relied on chemical catalytic processes using AMP or tetraacetylribose as substrates. These methods faced challenges, including demanding reaction conditions and the formation of isomeric byproducts, leading to persistently elevated production costs.

From: "Novel Biosynthetic Pathway for Nicotinamide Mononucleotide Production from Cytidine in Escherichia coli", Catalysts 2025, 15(9), 816;
Answer
The challenges in industrial-scale NMN production include harsh reaction conditions and the formation of isomeric byproducts, which increase production costs. There is a growing interest in developing biosynthetic approaches that are less demanding and have superior stereoselectivity.
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