What is the significance of using methanol as the diluting solvent for the reaction with p-dimethylaminobenzaldehyde (DMAB)?

Label:chem

Topic
The study examines the effect of different solvents on the formation of azo adducts between diazotized cephalosporins and DMAB. The choice of solvent can influence the stability and absorbance of the azo adducts.

From: "Novel spectrophotometric determinations of some cephalosporins following azo dye formation with p-dimethylaminobenzaldehyde", Arabian Journal of Chemistry, Volume 9, Supplement 2, November 2016, Pages S1272-S1282
Answer
Methanol was found to be the best diluting solvent for the reaction with DMAB. It provided the highest absorbance values compared to other solvents like water, ethanol, propan-1-ol, and propan-2-ol. Methanol likely stabilizes the azo adducts by creating a less polar environment, preventing hydrolytic decomposition and ensuring accurate spectrophotometric detection.
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