How has the use of antibiotics like colistin and cefiderocol changed over the study period, and what impact has this had on CRKP prevalence?

Label:chem

Topic
The study analyzed antibiotic consumption data from 2019 to 2024 to assess the potential correlation between increased antibiotic use and the rise in CRKP incidence. The use of colistin and newer antibiotics like cefiderocol was specifically examined.

From: "Emergence of Carbapenem-Resistant Klebsiella pneumoniae in a Romanian Infectious Diseases Hospital", Pathogens 2025, 14(9), 859;
Answer
There was a significant increase in colistin use from 11,787 therapeutic units (TU) in 2019 to 21,870 TU in 2024. This increase, along with the rise in the use of newer antibiotics, correlates with the increased prevalence of CRKP strains producing NDM+OXA48-like carbapenemases. The study suggests that increased use of injectable β-lactams and colistin may have contributed to the rise in these resistant strains, highlighting the need for better antibiotic stewardship programs.
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