How does the crude extract from Bacillus nakamurai Tie-10 disrupt the cellular integrity of Klebsiella pneumoniae?

Label:chem

Topic
The study explores the antimicrobial mechanism of the crude extract from Bacillus nakamurai Tie-10, focusing on its effects on the cellular structure of Klebsiella pneumoniae.

From: "Optimization of Fermentation Conditions for Antarctic Bacteria and Investigation of Its Antimicrobial Mechanism Against Klebsiella pneumoniae", Microorganisms 2025, 13(9), 2027;
Answer
The crude extract from Bacillus nakamurai Tie-10 disrupts the cellular integrity of Klebsiella pneumoniae by causing significant membrane damage, as evidenced by increased alkaline phosphatase (AKP) content in the culture medium and severe morphological alterations observed under scanning electron microscopy (SEM). This damage leads to cellular content leakage and loss of structural organization.
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