What is the role of p-dimethylaminobenzaldehyde-reactive substances in the collagen of streptozotocin-diabetic rats?

Label:chem

Topic
p-Dimethylaminobenzaldehyde (Ehrlich's reagent) reacts with certain substances in collagen to form a colored adduct, which is indicative of pyrrolic compounds. These compounds are associated with advanced glycation endproducts (AGEs) and are known to increase cross-linking in collagen, which can affect its biomechanical properties.

From: "p-Dimethylaminobenzaldehyde-reactive substances in tail tendon collagen of streptozotocin-diabetic rats: temporal relation to biomechanical properties and advanced glycation endproduct (AGE)-related fluorescence", Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Volume 1502, Issue 3, 15 November 2000, Pages 398-404
Answer
The p-dimethylaminobenzaldehyde-reactive substances in the collagen of streptozotocin-diabetic rats contribute to increased cross-linking, which is associated with reduced tendon mechanical strength and increased AGE-related fluorescence. These changes are indicative of advanced glycation and may serve as a tissue measure of prolonged hyperglycemia.
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