How does aminoguanidine affect the formation of p-dimethylaminobenzaldehyde-reactive substances in diabetic rat collagen?

Label:chem

Topic
Aminoguanidine is a known inhibitor of non-enzymatic glycation, which is a process that leads to the formation of advanced glycation endproducts (AGEs) and subsequent cross-linking in collagen.

From: "p-Dimethylaminobenzaldehyde-reactive substances in tail tendon collagen of streptozotocin-diabetic rats: temporal relation to biomechanical properties and advanced glycation endproduct (AGE)-related fluorescence", Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Volume 1502, Issue 3, 15 November 2000, Pages 398-404
Answer
Aminoguanidine significantly inhibits the formation of p-dimethylaminobenzaldehyde-reactive substances in diabetic rat collagen, indicating its role in reducing non-enzymatic glycation and subsequent cross-linking. This suggests that aminoguanidine can mitigate the negative effects of hyperglycemia on collagen properties.
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