How does the fluorescence of collagen relate to the presence of p-dimethylaminobenzaldehyde-reactive substances in diabetic rat collagen?

Label:chem

Topic
Collagen fluorescence can be an indicator of advanced glycation endproducts (AGEs), which are associated with the formation of p-dimethylaminobenzaldehyde-reactive substances.

From: "p-Dimethylaminobenzaldehyde-reactive substances in tail tendon collagen of streptozotocin-diabetic rats: temporal relation to biomechanical properties and advanced glycation endproduct (AGE)-related fluorescence", Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Volume 1502, Issue 3, 15 November 2000, Pages 398-404
Answer
The fluorescence of collagen, indicative of AGEs, is positively correlated with the content of p-dimethylaminobenzaldehyde-reactive substances in diabetic rat collagen. This suggests that the presence of these substances contributes to the overall fluorescence and indicates the extent of glycation and cross-linking in the collagen matrix.
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