How do different carbapenemases affect the susceptibility of CRKP strains to antibiotics like colistin and cefiderocol?

Label:chem

Topic
Carbapenemases are enzymes that confer resistance to carbapenem antibiotics, which are often the last resort for treating multidrug-resistant infections. The study evaluated the in vitro sensitivity of CRKP isolates to commonly used antibiotics and new molecules, highlighting the importance of the association of antibiotic resistance phenotypes of CRKP isolates with carbapenemase types.

From: "Emergence of Carbapenem-Resistant Klebsiella pneumoniae in a Romanian Infectious Diseases Hospital", Pathogens 2025, 14(9), 859;
Answer
The susceptibility of CRKP strains to colistin and cefiderocol varies significantly based on the type of carbapenemase they produce. For instance, in 2023, the susceptibility of NDM+OXA48-like isolates to colistin was 18%, and to cefiderocol was 66.3%. In 2024, these values were 18% and 73.5%, respectively. The study found that strains producing NDM+OXA48-like carbapenemases had lower susceptibility to colistin but showed some susceptibility to cefiderocol, indicating that the combination of carbapenemases significantly impacts antibiotic efficacy.
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