How does the crude extract from Bacillus nakamurai Tie-10 affect the expression of virulence-associated genes in Klebsiella pneumoniae?

Label:chem

Topic
Virulence-associated genes play a crucial role in the pathogenicity of Klebsiella pneumoniae. The study examines the effect of the crude extract from Bacillus nakamurai Tie-10 on the expression of key virulence genes in this pathogen.

From: "Optimization of Fermentation Conditions for Antarctic Bacteria and Investigation of Its Antimicrobial Mechanism Against Klebsiella pneumoniae", Microorganisms 2025, 13(9), 2027;
Answer
The crude extract from Bacillus nakamurai Tie-10 significantly downregulates the expression of virulence-associated genes in Klebsiella pneumoniae, including luxS, wabG, and fimH. The relative expression levels of these genes are reduced to 0.6-fold, 0.19-fold, and 0.1-fold compared to the control group, respectively. This downregulation suggests potent inhibitory effects on bacterial pathogenicity mechanisms.
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