What is the role of the crude extract from Bacillus nakamurai Tie-10 in inhibiting Klebsiella pneumoniae?

Label:chem

Topic
Bacillus nakamurai Tie-10 is a bacterial strain isolated from Antarctic samples that demonstrates potent antibacterial activity against Klebsiella pneumoniae, a pathogen that has developed resistance to multiple antibiotics. The study investigates the antimicrobial mechanism of the crude extract from this strain.

From: "Optimization of Fermentation Conditions for Antarctic Bacteria and Investigation of Its Antimicrobial Mechanism Against Klebsiella pneumoniae", Microorganisms 2025, 13(9), 2027;
Answer
The crude extract from Bacillus nakamurai Tie-10 effectively inhibits the growth of Klebsiella pneumoniae by disrupting cellular integrity, inhibiting extracellular protease secretion, downregulating virulence-associated genes, and preventing biofilm formation. These mechanisms collectively contribute to its potent antibacterial activity.
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