What is the significance of nicotinamide mononucleotide (NMN) in cellular metabolism and aging?

Label:chem

Topic
Nicotinamide mononucleotide (NMN) is an important precursor of nicotinamide adenine dinucleotide (NAD+), which is integral in cellular metabolism, energy generation, and processes associated with aging. NAD+ is involved in numerous cellular functions, such as mitochondrial health, aging, and immune response, making NMN a potential therapeutic agent for mitigating age-related diseases and metabolic disorders.

From: "Novel Biosynthetic Pathway for Nicotinamide Mononucleotide Production from Cytidine in Escherichia coli", Catalysts 2025, 15(9), 816;
Answer
NMN plays a crucial role in maintaining NAD+ levels, which are essential for energy metabolism, DNA repair, and stress response. It is a key molecule in pathways that regulate cellular aging and health, making it a target for biotechnological production and therapeutic applications.
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