What is the synergistic effect of Ferulic Acid (FA) with antibiotics against E. coli?

Label:chem

Topic
Biofilm-associated infections are often resistant to conventional antibiotics, necessitating the development of new therapeutic strategies. This study explores the potential synergistic effects of FA with clinically relevant antibiotics to enhance antimicrobial efficacy.

From: "Antibiofilm Inhibitor Ferulic Acid as an Antibacterial Synergist Against Escherichia coli", Biomolecules 2025, 15(9), 1253;
Answer
FA exhibits significant synergistic antibacterial effects when combined with fosfomycin sodium, ceftriaxone, gentamicin, and tetracycline. The most pronounced synergistic effect is observed with fosfomycin sodium. This combination therapy can potentially reduce the required concentration of antibiotics, making FA a promising candidate for combination therapy against drug-resistant E. coli infections.
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