Can the abundance of Fusobacterium nucleatum in gastric cancer tissues serve as a diagnostic biomarker?

Label:chem

Topic
Previous studies have shown that F. nucleatum is enriched in GC tissues and is associated with poor prognosis. The study investigates whether the abundance of F. nucleatum can be used as a diagnostic biomarker for GC.

From: "Fusobacterium nucleatum Infection Drives Glutathione Depletion in Gastric Cancer: Integrated Multi-Omics and Experimental Validation", Microorganisms 2025, 13(8), 1907;
Answer
Yes, the abundance of Fusobacterium nucleatum in GC tissues can serve as a diagnostic biomarker. The study found a significant correlation between F. nucleatum abundance and GSH depletion in GC tissues. Combining the detection of salivary F. nucleatum with tissue or serum GSH levels may enhance the precision of GC diagnosis, especially for early screening of Helicobacter pylori-negative GC.
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