What therapeutic strategies can be developed based on the F. nucleatum-GSH axis in gastric cancer?

Label:chem

Topic
The study identifies a novel mechanism by which F. nucleatum depletes GSH in GC cells, suggesting potential therapeutic targets for GC treatment.

From: "Fusobacterium nucleatum Infection Drives Glutathione Depletion in Gastric Cancer: Integrated Multi-Omics and Experimental Validation", Microorganisms 2025, 13(8), 1907;
Answer
Targeting the F. nucleatum-GSH axis offers several therapeutic strategies for GC treatment. These include: (1) antibacterial strategies targeting F. nucleatum to restore intracellular GSH homeostasis, (2) targeted oxidative therapies that exploit GSH depletion to selectively eradicate F. nucleatum-positive tumor cells, and (3) modulating the gastric microbiota through probiotics or dietary interventions to indirectly affect the GSH metabolic pathway. These strategies hold potential for improving the prognosis of GC patients.
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