How does rokitamycin compare to other macrolides in inducing apoptosis in leukemia cells?

Label:chem

Topic
Macrolides are a class of antibiotics with varying ring structures (14-, 15-, and 16-member rings). This study compares the apoptotic effects of 13 different macrolides, including rokitamycin, on leukemia cell lines.

From: "Rokitamycin Induces a Mitochondrial Defect and Caspase-Dependent Apoptosis in Human T-Cell Leukemia Jurkat Cells", Journal of Pharmacological Sciences, Volume 110, Issue 1, 2009, Pages 69-77
Answer
Among the 13 macrolides tested, rokitamycin is the most effective in inducing apoptosis in leukemia cells. The study concludes that rokitamycin's higher potency may be due to its greater ability to penetrate into the intracellular space compared to other macrolides.
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