What is the impact of raloxifene-tartaric acid complexes on cytotoxicity in breast cancer cells?

Label:chem

Topic
The cytotoxic potential of raloxifene and its complexes with functional excipients was evaluated in human breast cancer (MCF-7) cell lines to determine their efficacy in reducing cell viability.
Answer
Raloxifene-tartaric acid complexes exhibited significant cytotoxicity in MCF-7 breast cancer cells, with an IC50 value of 13.8 μg/mL, closely matching that of the standard anticancer drug paclitaxel (14.8 μg/mL). This enhanced cytotoxicity is attributed to the improved aqueous solubility and dissolution rate of raloxifene when complexed with tartaric acid, leading to better intracellular availability and interaction with cellular targets.
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