How do genetic variants in the ESR1 gene influence the treatment response to raloxifene in schizophrenia-spectrum disorders (SSD)?

Label:chem

Topic
Raloxifene is a selective estrogen receptor modulator (SERM) that may improve symptoms and cognition in schizophrenia-spectrum disorders (SSD). The estrogen receptor alpha (ER-α) is encoded by the ESR1 gene, and genetic variants in this gene can influence the function of the receptor. Raloxifene primarily binds to ER-α, and variations in ESR1 may affect the therapeutic effects of raloxifene.
Answer
The study found that the ESR1 rs2234693 TT genotype was associated with a beneficial effect of raloxifene on general symptom severity. Specifically, participants with the TT genotype showed a significant reduction in general symptom severity compared to those with the CT or CC genotypes. This suggests that genetic variants in the ESR1 gene may influence the efficacy of raloxifene in treating SSD.
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