How do genetic variants in the UGT1A8 gene influence the treatment response to raloxifene in schizophrenia-spectrum disorders (SSD)?

Label:chem

Topic
The UGT1A8 gene encodes UDP-glucuronosyltransferase 1A8, an enzyme involved in the metabolic pathway of raloxifene. Genetic variants in the UGT1A8 gene may affect the activity of this enzyme and thereby influence the bioavailability and efficacy of raloxifene.
Answer
The study did not find any significant treatment-by-genotype interactions for the UGT1A8 rs1042597 SNP. This suggests that genetic variants in the UGT1A8 gene did not significantly influence the treatment response to raloxifene in this sample of patients with SSD.
Return to Home Chemical List
Knowledge you may be interested in
How do genetic variants in the COMT gene influence the treatment response to raloxifene in schizophrenia-spectrum disorders (SSD)? How do genetic variants in the ESR1 gene influence the treatment response to raloxifene in schizophrenia-spectrum disorders (SSD)? How does the cellular uptake of raloxifene complexes with tartaric acid and HP β-CD compare in Caco-2 cells? What is the impact of raloxifene-tartaric acid complexes on cytotoxicity in breast cancer cells? How do pH-modifying excipients like tartaric acid and azelaic acid improve the solubility and dissolution of raloxifene? What is the role of cyclodextrins in enhancing the solubility and dissolution of raloxifene? How does raloxifene function as an anticancer agent in breast cancer treatment? What are the barriers to the use of mifepristone for EPL management in assisted reproductive technology (ART) pregnancies? How does the combination of mifepristone and misoprostol compare to misoprostol alone in managing EPL? Why is mifepristone not widely used by reproductive endocrinology and infertility specialists for EPL management? What is the antibacterial mechanism of riccardin C derivatives against MRSA? What is the role of IDPO-9 in the antibacterial activity against MRSA? What is the role of Riccardin C (RC) in modulating the activity of Liver X Receptors (LXRs)? How does Riccardin C (RC) affect cholesterol efflux in THP-1 cells? What is the role of Riccardin F (RF) in modulating the activity of Liver X Receptors (LXRs)? How does Riccardin C (RC) affect SREBP-1c expression in different cell types? What is the effect of β-Galactosylceramide (GalCer) on stratum corneum intercellular lipid synthesis and skin barrier function in a three-dimensional cultured human epidermis model? How to evaluate the physical and mechanical properties of atomoxetine tablets produced using SLS 3D printing? What is the significance of using hydroxypropyl methylcellulose (HPMC) in the formulation of SLS 3D printed atomoxetine tablets? What are the findings regarding the structural and chemical integrity of atomoxetine in SLS 3D printed tablets?