How does the cellular uptake of raloxifene complexes with tartaric acid and HP β-CD compare in Caco-2 cells?

Label:chem

Topic
The cellular uptake of FITC-labeled raloxifene complexes with tartaric acid and HP β-CD was evaluated in Caco-2 cells to understand their intracellular delivery and retention.
Answer
The cellular uptake study revealed that raloxifene-tartaric acid complexes exhibited superior uptake compared to raloxifene-HP β-CD complexes. The uptake was time- and concentration-dependent, with raloxifene-tartaric acid complexes showing significantly higher mean fluorescence intensity (MFI) values at both 4 hours and 24 hours. This suggests that tartaric acid complexes have better intracellular delivery and retention, likely due to their higher solubility and faster dissociation at the membrane interface.
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