How does TAK-285 perform in in vivo xenograft tumor models?

Label:chem

Topic
In vivo models are crucial for evaluating the efficacy of new drugs in a more biologically relevant context. TAK-285 has been tested in mouse and rat xenograft models to assess its antitumor activity.
Answer
TAK-285 demonstrated significant antitumor activity in both mouse and rat xenograft models. In mice, TAK-285 inhibited the growth of BT-474 breast tumors and 4-1ST gastric tumors with T/C values of 29% and 11%, respectively. In rats, it inhibited the growth of tumors overexpressing HER2 (4-1ST) or EGFR (A-431) with T/C values of 14% and 13%, respectively. These results confirm its efficacy in inhibiting tumor growth in vivo.
Return to Home Chemical List
Knowledge you may be interested in
What is the significance of TAK-285's activity against various tumor cell lines? How does TAK-285 differ from lapatinib in terms of P-glycoprotein (Pgp) substrate activity? What is the role of TAK-285 in inhibiting HER2 and EGFR kinases? What are the common adverse events associated with TAK-285 treatment? What are the pharmacokinetic properties of TAK-285 and its metabolite M-I? What is the role of TAK-285 in targeting HER2 and EGFR in cancer treatment? What is the significance of using a TBDMS group in the C3-chlorination of benzo[b]thiophene derivatives? How does the presence of a benzylic alcohol group affect the C3-chlorination reaction of benzo[b]thiophene derivatives? What is the role of N-chlorosuccinimide (NCS) in comparison to sodium hypochlorite in the C3-chlorination of benzo[b]thiophene derivatives? What is the effect of benzofuran on the C3-chlorination reaction when used in place of benzo[b]thiophene? What are the implications of TAK-285's activity in a brain metastasis model? What is the role of orexin-A and orexin-B in the regulation of arousal and sleep-wake balance? What is the mechanism of action of almorexant, the dual orexin receptor antagonist (DORA)? How does almorexant affect hormone levels in healthy male subjects? What is the effect of almorexant on tear film break-up time (TFBUT) in healthy male subjects? How does almorexant affect spermatogenesis in healthy male subjects? What role does Artesunate (ART) play in inhibiting metastatic potential in bladder cancer cells? How does Artesunate (ART) affect integrin expression in bladder cancer cells? What is the effect of Artesunate (ART) on the metastatic behavior of cisplatin-resistant bladder cancer cells? How does Artesunate (ART) impact the adhesion and motility of bladder cancer cells?