How does Ferulic Acid (FA) affect the transcription of biofilm-related genes in E. coli?

Label:chem

Topic
Biofilm formation in E. coli is regulated by various genes, including those related to curli fibers (csgD), flagella (flhC, flhD, motA), type I fimbriae (fimA), and c-di-GMP metabolism (pdeR, pdeA, dosP). Understanding the effect of FA on these genes can provide insights into its antibiofilm mechanism.

From: "Antibiofilm Inhibitor Ferulic Acid as an Antibacterial Synergist Against Escherichia coli", Biomolecules 2025, 15(9), 1253;
Answer
FA significantly downregulates the expression of csgD (43.32% reduction), flhC (23.14%), flhD (45.36%), motA (14.62%), and fimA (63.24%), while upregulating the transcription of pdeR (569.10% increase), pdeA (45.35%), and dosP (26.02%). This suggests that FA inhibits biofilm formation by suppressing the expression of genes involved in bacterial adhesion and motility and by promoting the degradation of c-di-GMP, which is crucial for biofilm development.
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