What is the role of Ferulic Acid (FA) in inhibiting biofilm formation by Escherichia coli (E. coli)?

Label:chem

Topic
Ferulic Acid (FA) is a natural phenolic compound found in fruits, vegetables, and grains. It has been reported to possess various biological activities, including anti-inflammatory, antioxidant, and antitumor properties. This study investigates the inhibitory effect of FA on the biofilm formation of E. coli, a foodborne pathogen known for its robust biofilm-forming capabilities, which can reduce antibiotic sensitivity and enhance bacterial virulence.

From: "Antibiofilm Inhibitor Ferulic Acid as an Antibacterial Synergist Against Escherichia coli", Biomolecules 2025, 15(9), 1253;
Answer
FA significantly inhibits biofilm formation by E. coli without affecting bacterial growth or metabolic activity. It reduces the production of extracellular polymeric substances (EPS) and weakens bacterial motility. The study also shows that FA downregulates the expression of biofilm-related genes, such as csgD, flhC, flhD, motA, and fimA, while upregulating the transcription of c-di-GMP-related genes (pdeR, pdeA, and dosP). This dual mechanism of action makes FA a promising candidate for treating E. coli infections.
Return to Home Chemical List
Knowledge you may be interested in
What are the potential pharmaceutical applications of tocotrienols extracted from Hypericum perforatum L.? How does the re-extraction process with 96.2% ethanol affect the recovery of tocopherols and tocotrienols from Hypericum perforatum L. inflorescences? What is the most efficient ethanol concentration for extracting tocopherols and tocotrienols from Hypericum perforatum L. inflorescences? What tocopherols and tocotrienols are found in Hypericum perforatum L. inflorescences? What are the effects of vitamin E on neuroinflammation and oxidative stress in the brain? How does vitamin E supplementation affect cognitive performance in humans? What are the roles of vitamin E isomers in neuroprotection? How do tocotrienol and tocopherol differ in their effects on brain health? What are the effects of tocotrienol and tocopherol supplementation on brain health? What is the role of the CB2 receptor in the antihyperalgesic effect of 4-methylaminoantipyrine (4-MAA)? How does Ferulic Acid (FA) affect the transcription of biofilm-related genes in E. coli? What is the synergistic effect of Ferulic Acid (FA) with antibiotics against E. coli? What is the role of Escherichia coli (E. coli) in biofilm formation and its impact on human and animal health? What is the impact of biofilm formation by Escherichia coli (E. coli) on antibiotic resistance and treatment efficacy? What is the significance of nicotinamide mononucleotide (NMN) in cellular metabolism and aging? How is nicotinamide mononucleotide (NMN) typically synthesized in biological systems? What challenges are associated with the industrial-scale production of nicotinamide mononucleotide (NMN)? How was the NMN biosynthetic pathway implemented in E. coli for intracellular production? What volatile organic compounds (VOCs) are produced by Escherichia coli, and how do their profiles differ between susceptible and resistant strains? What is the relationship between specific phylogenetic lineages of Klebsiella pneumoniae and the risk of death in bloodstream infections?