How does rokitamycin induce apoptosis in leukemia cells?

Label:chem

Topic
Apoptosis is a form of programmed cell death that involves the activation of caspases and mitochondrial perturbation. This study examines the specific mechanisms by which rokitamycin induces apoptosis in leukemia cells.

From: "Rokitamycin Induces a Mitochondrial Defect and Caspase-Dependent Apoptosis in Human T-Cell Leukemia Jurkat Cells", Journal of Pharmacological Sciences, Volume 110, Issue 1, 2009, Pages 69-77
Answer
Rokitamycin induces apoptosis by directly affecting mitochondria, causing a reduction in ΔΨm and the release of cytochrome c. This cytochrome c release precedes caspase activation, indicating that mitochondrial perturbation is an upstream event in the apoptotic pathway. The study concludes that rokitamycin-induced apoptosis is caspase-dependent and primarily mediated through mitochondrial pathways.
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