How does Riccardin C (RC) affect SREBP-1c expression in different cell types?

Label:chem

Topic
Sterol regulatory element-binding protein-1c (SREBP-1c) is a key regulator of lipogenesis and is upregulated by LXR activation. The expression of SREBP-1c can vary between different cell types, affecting lipid metabolism.
Answer
Riccardin C (RC) increases SREBP-1c mRNA levels in THP-1 cells, indicating its role in promoting lipogenesis in these cells. However, RC does not affect SREBP-1c expression in HepG2 cells, suggesting that its effects on SREBP-1c are cell type-specific. This difference may be due to the varying expression levels of LXRα and LXRβ in different cell types or the presence of different coactivator-corepressor complexes. The selective action of RC on SREBP-1c expression highlights the complexity of LXR signaling in different cellular contexts.
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