What is the effect of β-Galactosylceramide (GalCer) on stratum corneum intercellular lipid synthesis and skin barrier function in a three-dimensional cultured human epidermis model?

Label:chem

Topic
β-Galactosylceramide (GalCer) is a glycosphingolipid used in some cosmetics and quasidrugs for its anticipated moisturizing effect. It promotes keratinocyte differentiation and increases ceramide (CER) production by enhancing β-glucocerebrosidase (β-GCase) activity. However, the detailed mechanisms of these effects and the role of GalCer in intercellular lipid production in the stratum corneum (SC) have not been extensively studied.
Answer
GalCer treatment in a three-dimensional cultured human epidermis model increases the expression of genes involved in the β-GCase metabolic pathway, promotes CER production, and reduces the expression of free fatty acid (FFA) metabolism-related genes and palmitic acid levels. Additionally, GalCer treatment significantly reduces transepidermal water loss (TEWL), indicating improved skin barrier function. The findings suggest that GalCer, which is hardly metabolized, affects the production of intercellular lipids in the SC and improves skin barrier function.
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