How to evaluate the physical and mechanical properties of atomoxetine tablets produced using SLS 3D printing?

The study aims to compare the physical and mechanical properties of atomoxetine tablets produced using SLS 3D printing with those produced by conventional direct compression methods. The evaluation includes tablet weight, diameter, thickness, hardness, disintegration time, and drug content.

The study found that SLS tablets exhibited comparable mechanical properties and drug content to those made by direct compression. Lower laser speeds produced harder tablets with slower disintegration, while higher speeds yielded more porous tablets with ultra-rapid drug release. All tablets met the European Pharmacopoeia dissolution criteria.