What is the role of IDPO-9 in the antibacterial activity against MRSA?

Label:chem

Topic
IDPO-9 is a partial structure of riccardin C and has been shown to have weaker anti-MRSA activity compared to the riccardin C derivatives. The specific mechanism of action of IDPO-9 was not clear.
Answer
IDPO-9 exhibits bacteriostatic effects against MRSA by inhibiting FabI, an enoyl-acyl carrier protein reductase. This conclusion is supported by the isolation of IDPO-9-resistant mutants that showed cross-resistance to triclosan, a known inhibitor of FabI. IDPO-9 inhibits FabI to exert its bacteriostatic effects against MRSA, which is different from the bactericidal mechanism of riccardin C derivatives.
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