What is the role of titanium tetrachloride (TiCl4) in the synthesis of (-)-halenaquinone?

Label:chem

Topic
Titanium tetrachloride (TiCl4) is used in the hydrolysis step of the synthesis.
Answer
Titanium tetrachloride (TiCl4) is used to hydrolyze the thiophenyl group in compound 14, producing the pentacyclic precursor (15) to (-)-halenaquinone. This step is essential for removing the protecting group and obtaining the final precursor needed for the synthesis of (-)-halenaquinone.
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