What is the role of tacrolimus in the management of ocular surface diseases?

Label:chem

Topic
Tacrolimus is an immunosuppressant that has gained attention for its topical use in ophthalmology, particularly for conditions like vernal keratoconjunctivitis (VKC) and post-keratoplasty rejection prophylaxis.
Answer
Tacrolimus is effective in improving clinical signs and symptoms in most patients with ocular surface diseases. It has shown superior efficacy compared to control groups in some studies and equivalent efficacy in others. It is particularly useful in managing VKC, dry eye secondary to Sjogren syndrome, ocular graft-versus-host disease (GVHD), adenoviral corneal subepithelial infiltrates (SEIs), and acute endothelial graft rejection after penetrating keratoplasty (PKP).
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