What are the advantages of using tacrolimus over corticosteroids in ocular graft-versus-host disease (GVHD)?

Label:chem

Topic
GVHD is a condition where donor immune cells attack the recipient's tissues, often affecting the ocular surface.
Answer
Tacrolimus demonstrated superior efficacy in reducing corneal staining compared to methylprednisolone. Additionally, tacrolimus did not significantly increase intraocular pressure (IOP), unlike corticosteroids, making it a safer option for long-term use in managing GVHD-related dry eye.
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