What are the potential targets of allosamidin in asthma?

Label:chem

Topic
Understanding the molecular targets of allosamidin in asthma can help in elucidating its mechanism of action and identifying new therapeutic targets.
Answer
Allosamidin and demethylallosamidin bind to chitinase-like proteins such as Ym1 and BRP-39, which are upregulated in asthma models. These proteins are involved in eosinophil chemotaxis and Th2 cytokine production. The binding of allosamidin to these proteins may inhibit their pro-inflammatory functions, contributing to its anti-asthmatic activity.
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