What is the effect of Olprinone (OLP) on pro-inflammatory cytokines and chemokines in the liver?

Label:chem

Topic
Pro-inflammatory cytokines and chemokines play a critical role in the progression of liver injury after hepatectomy and endotoxin exposure.
Answer
Olprinone (OLP) significantly decreased the mRNA expression of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and C-X-C motif chemokine ligand 1 (CXCL1) in the livers of rats treated with partial hepatectomy and LPS. Additionally, OLP reduced serum levels of TNF-α, IL-6, and IL-1β, indicating its ability to suppress the transcription of these inflammatory mediators through the inhibition of NF-κB activation.
Return to Home Chemical List
Knowledge you may be interested in
How does Olprinone (OLP) affect survival rates in rats subjected to partial hepatectomy and LPS treatment? What is the role of Olprinone (OLP) in hepatoprotection after partial hepatectomy and endotoxin-induced liver injury? What is the role of tacrolimus in preventing acute endothelial graft rejection after penetrating keratoplasty (PKP)? How does tacrolimus perform in treating adenoviral corneal subepithelial infiltrates (SEIs)? What are the advantages of using tacrolimus over corticosteroids in ocular graft-versus-host disease (GVHD)? How effective is tacrolimus in managing dry eye secondary to Sjogren syndrome? What are the common side effects of topical tacrolimus in ocular conditions? How does tacrolimus compare to other treatments in terms of efficacy for vernal keratoconjunctivitis (VKC)? What is the role of tacrolimus in the management of ocular surface diseases? What are the potential targets of allosamidin in asthma? How does Olprinone (OLP) influence inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in the liver? What histopathological changes are observed in the liver after treatment with Olprinone (OLP)? How does Olprinone (OLP) affect NF-κB activation in hepatocytes? What are the potential clinical implications of using Olprinone (OLP) for hepatoprotection? What is the role of lanreotide in the treatment of gastroenteropancreatic neuroendocrine tumors (NETs)? How does lanreotide affect T cell function and survival in vitro? What are the in vivo effects of lanreotide on T cell gene expression in NET patients? Which specific genes were differentially expressed in responders versus non-responders before lanreotide treatment? How does lanreotide treatment affect T cell signaling pathways in vivo? How does the intranasal delivery of granisetron via nanostructured cubosomes improve the management of chemotherapy-induced emesis?