How does Caly A's effect on calcium influx differ between fibroblasts and breast cancer cells?

Label:chem

Topic
A study examines the differential effects of Caly A on calcium influx in Hs-68 fibroblasts and MDA-MB-468 breast cancer cells.
Answer
In Hs-68 fibroblasts, Caly A blocks serum-induced calcium influx, while in MDA-MB-468 breast cancer cells, it does not. This suggests that breast cancer cells may utilize alternative calcium entry pathways that are not affected by Caly A.
Return to Home Chemical List
Knowledge you may be interested in
Does Caly A affect the expression of cyclin D1 at low doses? What effect does Caly A have on intracellular calcium levels in fibroblasts? Why are breast cancer cells resistant to the effects of low-dose Calyculin A (Caly A)? How does Calyculin A (Caly A) affect cell cycle progression in non-cancerous fibroblasts and epithelial cells? What is the dual action of Calyculin A (Caly A)? How do the yields of quinones and diquinones vary with different ceric ammonium nitrate (CAN) addition methods? What are the key findings regarding the synthesis of quinones and diquinones from para-halogenated benzyl derivatives of 1,4-dimethoxybenzene? What is the role of trifluoroacetic acid (TFA) and triethylsilane (TES) in the synthesis of benzyl derivatives 3a and 3b? How does the addition method of ceric ammonium nitrate (CAN) affect the quinone/diquinone ratio in the oxidation of 2-benzyl-1,4-dimethoxybenzene derivatives? What is the significance of quinone compounds in biological processes? What is the effect of calyculin A (cal A) on γH2AX DNA repair foci in irradiated human umbilical cord blood lymphocytes (UCBL)? How does calyculin A (cal A) affect apoptosis in human umbilical cord blood lymphocytes (UCBL)? How does calyculin A (cal A) affect the kinetics of DNA repair foci formation in irradiated cells? What is the structure and biosynthesis of allosamidin? How does allosamidin inhibit family 18 chitinases? What are the biological activities of allosamidin in Streptomyces? How does allosamidin affect chitinase production in Streptomyces? What is the anti-asthmatic activity of allosamidin and demethylallosamidin? What are the potential targets of allosamidin in asthma? What is the role of tacrolimus in the management of ocular surface diseases?