How does calyculin A (cal A) affect apoptosis in human umbilical cord blood lymphocytes (UCBL)?

Label:chem

Topic
Apoptosis is a form of programmed cell death that can be triggered by various stressors, including DNA damage. Calyculin A (cal A) is known to induce apoptosis in certain cell types, but its effects on UCBL have not been thoroughly investigated.
Answer
Cal A (10 nM) induced apoptosis in UCBL within 2 hours of treatment, independent of the delivered radiation dose. Apoptosis was also detected in UCBL treated with 1 nM cal A at longer incubation times (20 and 44 hours). The study suggests that cal A-induced apoptosis may underlie the failure of cal A to maintain radiation-induced γH2AX foci.
Return to Home Chemical List
Knowledge you may be interested in
What is the effect of calyculin A (cal A) on γH2AX DNA repair foci in irradiated human umbilical cord blood lymphocytes (UCBL)? How does Caly A's effect on calcium influx differ between fibroblasts and breast cancer cells? Does Caly A affect the expression of cyclin D1 at low doses? What effect does Caly A have on intracellular calcium levels in fibroblasts? Why are breast cancer cells resistant to the effects of low-dose Calyculin A (Caly A)? How does Calyculin A (Caly A) affect cell cycle progression in non-cancerous fibroblasts and epithelial cells? What is the dual action of Calyculin A (Caly A)? How do the yields of quinones and diquinones vary with different ceric ammonium nitrate (CAN) addition methods? What are the key findings regarding the synthesis of quinones and diquinones from para-halogenated benzyl derivatives of 1,4-dimethoxybenzene? What is the role of trifluoroacetic acid (TFA) and triethylsilane (TES) in the synthesis of benzyl derivatives 3a and 3b? How does calyculin A (cal A) affect the kinetics of DNA repair foci formation in irradiated cells? What is the structure and biosynthesis of allosamidin? How does allosamidin inhibit family 18 chitinases? What are the biological activities of allosamidin in Streptomyces? How does allosamidin affect chitinase production in Streptomyces? What is the anti-asthmatic activity of allosamidin and demethylallosamidin? What are the potential targets of allosamidin in asthma? What is the role of tacrolimus in the management of ocular surface diseases? How does tacrolimus compare to other treatments in terms of efficacy for vernal keratoconjunctivitis (VKC)? What are the common side effects of topical tacrolimus in ocular conditions?