What is the anti-asthmatic activity of allosamidin and demethylallosamidin?

Label:chem

Topic
Asthma is a chronic inflammatory disease characterized by eosinophilic infiltration and airway hyperresponsiveness. Identifying new therapeutic agents is crucial for managing asthma, especially intractable cases.
Answer
Allosamidin and demethylallosamidin exhibit anti-asthmatic activity by inhibiting acidic mammalian chitinase (AMCase). Demethylallosamidin is more effective than allosamidin in reducing eosinophil counts, eotaxin concentration, and airway hyperresponsiveness in an IL-13-induced asthma mouse model. This suggests that demethylallosamidin has superior potential as an anti-asthmatic agent.
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