What is the role of tacrolimus in preventing acute endothelial graft rejection after penetrating keratoplasty (PKP)?

Label:chem

Topic
PKP is a surgical procedure to replace a damaged cornea, and graft rejection is a significant concern post-surgery.
Answer
Tacrolimus, when used as an adjuvant to prednisolone, significantly reduced the time to rejection reversal and the recurrence rate of rejection episodes. This suggests that tacrolimus can enhance the speed and durability of rejection management in PKP patients.
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